Michal Kwiatkowski and Egan Bernal pushed hard in the breakaway on stage three at Etoile de Besseges, with Kwiato taking a top-10 finish.
The Grenadiers duo made their way into a high-calibre move after an attacking start to the day.
Bernal rode hard for his teammate in the closing stages as he continues his return to racing. Kwiatkowski was 10th at the line, and now sits fourth overall, 48 seconds back on leader Tim Wellens (Lotto Soudal).
Michal Kwiatkowski took fifth place on a punchy uphill finish in Bellegarde as the INEOS Grenadiers got their season under way in France.
After spending much of the stage at the rear of the peloton, the team hit the front in time for the final 15km, with Geraint Thomas leading the charge.
Egan Bernal was held up behind a crash that split the peloton late on but suffered no issues on the run-in as he returns to racing.
With Kwiatkowski fifth, two seconds behind victor Christophe Laporte (Cofidis), there was also a strong ride from Filippo Ganna to finish on the same time as a number of rivals. The Italian has a firm eye on the final day time trial and sits just two seconds off the lead.