Pavel Sivakov has been forced to withdraw from the Giro d'Italia after suffering a shoulder injury on stage five.
INEOS Grenadiers Doctor Derick Macleod said: "Pavel has unfortunately landed heavily on his shoulder and damaged a plate he had in his clavicle from a previous injury, so he will need surgery to fix this and we are planning specialist orthopaedic assessment as soon as possible.
Sport Director Matteo Tosatto said: "Today is a bad day for us because Pavel had a big crash with 15km to go. There were a lot of small towns and roads, then when he crashed he immediately felt pain.
"He finished the stage, but in the end after the check in hospital they found a fracture in his collarbone, and he's abandoned the race. Pavel had an important role, he was the second leader for GC, and a key support rider for Egan in the mountains.
"Now it's important that the other guys stay strong because of having one guy less, but at the same time it's important to support each other and stay positive. It's difficult, but it's important to stay positive."